Mathematical Modeling of Planar Polarity
نویسندگان
چکیده
منابع مشابه
Mathematical modeling of planar cell polarity to understand domineering nonautonomy.
Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled, cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering...
متن کاملDomineering Nonautonomy Mathematical Modeling of Planar Cell Polarity
http://www.sciencemag.org/cgi/content/full/307/5708/423 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/307/5708/423/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...
متن کاملModeling the control of planar cell polarity.
A growing list of medically important developmental defects and disease mechanisms can be traced to disruption of the planar cell polarity (PCP) pathway. The PCP system polarizes cells in epithelial sheets along an axis orthogonal to their apical-basal axis. Studies in the fruitfly, Drosophila, have suggested that components of the PCP signaling system function in distinct modules, and that the...
متن کاملMathematical Modeling of Sub-Cellular Asymmetry of Fat-Dachsous Heterodimer for Generation of Planar Cell Polarity
Planar Cell Polarity (PCP) is an evolutionarily conserved characteristic of animal tissues marked by coordinated polarization of cells or structures in the plane of a tissue. In insect wing epithelium, for instance, PCP is characterized by en masse orientation of hairs orthogonal to its apical-basal axis and pointing along the proximal-distal axis of the organ. Directional cue for PCP has been ...
متن کاملSupporting Online Material for “Mathematical modeling of planar cell polarity to understand domineering non-autonomy”
Supporting Text . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 The Factor X or Z model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Mathematical model formulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Numerical methods . . . . . . ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2005
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2005.01.007